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il colpevole della placca dentale. E’ un enzima e si chiama “glucansucrasi”","ecco-colpevole-placca-dentale-enzima-chiama-glucansucrasi","Un gruppo di ricercatori dell'università di Groningen, nei Paesi Bassi ha individuato il colpevole della formazione della placca dentale, un enzima che converte lo zucchero del cibo in lunghe catene…","\u003Cp>Un gruppo di ricercatori dell'università di Groningen, nei Paesi Bassi ha individuato il colpevole della formazione della placca dentale, un enzima che converte lo zucchero del cibo in lunghe catene di zuccheri che si attaccano letteralmente ai denti. Secondo quanto ha riportato l’agenzia \u003Ci>Ansa\u003C\u002Fi>, per combattere la placca basterà identificare la sostanza che blocca l'azione dell'enzima, aggiungerla a dentifrici o trattamenti dentali.\u003C\u002Fp>\u003Cp> Per effettuare la ricerca pubblicata su \u003Ca href=\"http:\u002F\u002Fwww.pnas.org\u002F\">Proceedings of National Academy of Sciences\u003C\u002Fa> i ricercatori hanno studiato l'enzima glucansucrasi dal batterio Lactobacillus reuteri, presente nella bocca e nel tratto digestivo dell'uomo. Il Lactobacillus usa l'enzima per convertire lo zucchero contenuto nel cibo in catene di zuccheri che si attaccano ai denti. Anche lo Streptococcus mutans, il batterio responsabile della carie utilizza lo stesso meccanismo. Una volta collegati allo smalto dei denti, questi batteri fermentano gli zuccheri liberando acidi che dissolvono il calcio nei denti, provocando la carie. \u003C\u002Fp>\u003Cp>Il gruppo olandese, spiega \u003Ci>l’Ansa\u003C\u002Fi>, ha osservato la struttura dell'enzima della placca in tre dimensioni grazie alla cristallografia, per individuare eventuali inibitori del suo funzionamento. ''Finora la ricerca non ha dato risultati sugli inibitori - ha affermato all’\u003Ci>Ansa\u003C\u002Fi> Lubbert Dijkhuizen, uno degli autori dello studio - poichè quelli studiati finora inibivano sia l'enzima glucansucrase che l'enzima digestivo amilasi, presente nella saliva e necessario per degradare l'amido''. Dalle immagini in 3D dell'enzima della placca, i ricercatori hanno potuto osservare che è molto simile all'amilasi. ''I siti attivi sono praticamente identici'' ha proseguito Dijkhuizen. Pertanto, gli inibitori dovranno ''essere indirizzati verso obiettivi molto specifici - ha concluso l'autore della ricerca - perchè entrambi gli enzimi sono strettamente correlati dal punto di vista evolutivo''.\u003C\u002Fp>","cc9d7d14-397a-472c-b99c-11c5993f28cd","published","public","2010-12-06T00:00:00+00:00","2026-08-07T09:28:58.833014+00:00","'3d':273C 'academy':120C 'acid':190C 'afferm':237C 'agenz':89C 'aggiung':105C 'amid':269C 'amilas':260C,288C 'ansa':90C,205C,239C 'attacc':80C,161C 'attiv':291C 'autor':244C,311C 'azion':102C 'bass':24B,55C 'bast':95C 'batter':131C,169C,185C 'blocc':100C 'bocc':136C 'calc':194C 'car':172C,199C 'caten':44B,75C,156C 'chiam':12A 'cib':41B,72C,154C 'colleg':179C 'colpevol':3A,28B,59C 'combatt':92C 'conclus':309C 'conten':152C 'convert':37B,68C,149C 'correl':320C 'cristallograf':219C 'dat':232C 'degrad':267C 'dent':83C,163C,183C,196C 'dental':6A,33B,64C,110C 'dentifr':107C 'digest':140C,259C 'dijkhuizen':241C,297C 'dimension':216C 'dissolv':192C 'dovrann':301C 'ecco':1A 'effettu':112C 'entramb':315C 'enzim':9A,35B,66C,104C,128C,147C,211C,254C,258C,275C,317C 'esser':302C 'eventual':222C 'evolut':325C 'ferment':186C 'finor':227C,250C 'formazion':30B,61C 'funzion':226C 'glucansucras':13A,129C,255C 'graz':217C 'groningen':21B,52C 'grupp':15B,46C,201C 'ident':294C 'identific':96C 'immagin':271C 'indirizz':303C 'individu':26B,57C,221C 'inib':251C 'inibitor':223C,235C,300C 'lactobacillus':132C,144C 'letteral':81C 'liber':189C 'lubbert':240C 'lung':43B,74C 'meccan':176C 'molt':285C,306C 'mutans':167C 'national':119C 'necessar':265C 'obiett':305C 'of':118C,121C 'olandes':202C 'osserv':207C,282C 'paes':23B,54C 'perc':314C 'pertant':298C 'placc':5A,32B,63C,94C,213C,277C 'poic':247C 'pot':281C 'pratic':293C 'present':134C,261C 'proceedings':117C 'prosegu':296C 'provoc':197C 'pubblic':115C 'punt':322C 'respons':170C 'reuter':133C 'ricerc':17B,48C,114C,124C,229C,279C,313C 'riport':87C 'risult':233C 'sal':263C 'sciences':122C 'second':84C 'simil':286C 'sit':290C 'smalt':181C 'sostanz':98C 'specif':307C 'spieg':203C 'stess':175C 'streptococcus':166C 'strett':319C 'struttur':209C 'stud':126C,246C,249C 'tratt':109C,139C 'tre':215C 'univers':19B,50C 'uom':142C 'usa':145C 'utilizz':173C 'vers':304C 'vist':324C 'volt':178C 'zuccher':39B,70C,77C,151C,158C,188C",[],1291,[],[228],{"categories":229,"category_id":20},{"name":21,"path":22,"slug":22},{"bio":231,"title":8,"last_name":8,"avatar_url":8,"first_name":232,"is_organization":9},"Notizie e aggiornamenti dal mondo dell'odontoiatria.","Redazione ilDentale",[234,244,254],{"id":235,"title":236,"slug":237,"category_prefix":22,"excerpt":238,"cover_image_url":8,"access_level":220,"published_at":239,"article_categories":240,"authors":243},"b25a1b1b-5941-4e73-857d-75a4bed2f99e","Al via la terza edizione del Master in “Sviluppo della salute del cavo orale nelle comunità svantaggiate e nei Paesi in via di sviluppo”","via-terza-edizione-master-sviluppo-salute-cavo-orale","Sono disponibili ancora qualche posto per la terza edizione del Master di primo livello in “Sviluppo della salute del cavo orale nelle comunità svantaggiate e nei Paesi in via di sviluppo. 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