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Ne consegue che la prevalenza di determinati microorganismi può essere non tanto la causa della malattia ma il suo risultato: in quanto i microbi più resistenti sono proprio quelli che più sono in grado di adattarsi alle mutate condizioni ambientali magari aggregandosi tra specie differenti per meglio adattarsi ad un ambiente ostile. Per quanto riguarda le infezioni endodontiche i patogeni più pericolosi possono essere entità polimicrobiche capaci di modificarsi geneticamente e fisiologicamente in risposta a cambiamenti delle condizioni ambientali all’interno del canale radicolare. \u003C\u002Fp>\u003Cp>Un articolo pubblicato sul Corriere Medico (2008;11:45-56) ha spiegato che per poter individuare la migliore tecnica per eliminare i batteri è importante capire le differenze tra i diversi ambienti in cui i batteri si trovano ad agire in particolare tra canali trattati o non trattati endodonticamente; un canale radicolare infetto, non trattato, presenta peptidi e amminoacidi che favoriscono la crescita di microorganismi che trovano nutrimento con facilità, mentre in un canale ben trattato endodonticamente, in cui la polpa necrotica è stata eliminata, è difficile per molte specie di microbi trovare nutrimento sufficiente a sopravvivere. 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