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CLINICA: attenzione all’interazione tra i farmaci","ricerca-clinica-attenzione-all-interazione-farmaci","Interessante questo dossier pubblicato su Dental Cadmos n°3\u002F2013 (“ Reazioni avverse e interazioni farmacologiche di interesse odontoiatrico” di S. Devani, E. Baruzzi, V.Martini, G. Ficarra, G. Lodi)…","\u003Cp>Interessante questo dossier pubblicato su \u003Ca href=\"http:\u002F\u002Fwww.dentalcadmos.com\u002F\">Dental Cadmos\u003C\u002Fa> n°3\u002F2013 (“ Reazioni avverse e interazioni farmacologiche di interesse odontoiatrico” di S. Devani, E. Baruzzi, V.Martini, G. Ficarra, G. Lodi) che fornisce all'odontoiatra uno strumento di consultazione sulle possibili reazioni avverse ai farmaci e sulle interazioni tra i principi attivi più prescritti per la salute generale ed i farmaci comunemente utilizzati in ambito odontoiatrico. \u003C\u002Fp>\u003Cp>Capita spesso nella nostra pratica quotidiana di prescrivere farmaci, in particolare antibiotici ed antinfiammatori, a pazienti affetti da più patologie e quindi in terapia con numerose sostanze.\u003C\u002Fp>\u003Cp>Gli autori hanno incrociato i dati scientifici estrapolati da diversi database per ogni singolo principio attivo dei 15 più prescritti in Italia nei primi nove mesi del 2011, ottenendo un’utile guida riassuntiva in una tabella rapidamente consultabile, facilitando la gestione del paziente in multiterapia. \u003C\u002Fp>\u003Cp>Alcune prescrizioni sono in costante aumento ( ad es gli antiulcera), altre subiscono un’impennata di vendita dovuta allo scadere del brevetto da parte della casa farmaceutica (ad es. il valsartan). C’è da notare che tutti i principi attivi più utilizzati nel nostro paese sono in grado di portare all'instaurarsi di eventi avversi generali e di interesse odontoiatrico. \u003C\u002Fp>\u003Cp>Facciamo quindi attenzione nella prescrizione di farmaci utilizzati di routine e spesso considerati \"innocui\"come antimicrobici e antidolorifici; queste molecole spesso interagiscono con altre sostanze portando ad effetti nocivi sullo stato di salute generale. La maggior parte degli effetti sono di lieve entità, anche se per il paziente molto fastidiosi, come la xerostomia e la disgeusia (bocca che brucia), ma in alcuni casi si possono manifestare disturbi gravi, quali angioedema ed eritema multiforme, potenzialmente scatenati da più della metà dei farmaci maggiormente prescritti nel nostro paese. Utile la tabella pubblicata dagli Autori che vi ripropongo:\u003C\u002Fp>\u003Ctable>\u003Ctbody>\u003Ctr>\u003Ctd>\u003Cp>\u003Cb>Principio attivo\u003C\u002Fb>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>\u003Cb>Categoria\u003C\u002Fb>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>\u003Cb>Reazioni avverse di interesse odontoiatrico\u003C\u002Fb>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>\u003Cb>Interazioni con antibiotici (AB), antinfiammatori non steroidei \u003Cbr\u002F>(FANS) e altri farmaci di utilizzo odontoiatrico\u003C\u002Fb>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Ramipril\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antipertensivo \u003Cbr\u002F>ACE-inibitore\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, \u003Cbr\u002F>discromie dentali, \u003Cbr\u002F>disgeusia, eritema multiforme, \u003Cbr\u002F>pemfigo, scialorrea, xerostomia\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS: antagonismo dell'effetto ipotensivo e aumento \u003Cbr\u002F>del rischio d'insufficienza renale; con ketorolac e forse altri FANS, ipercaliemia\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Acido acetilsalicilico\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, emorragia gengivale, eritema multiforme erosioni e ulcerazioni\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS: l’uso concomitante di altri FANS aumenta il rischio di effetti collaterali; l'Ibuprofene può ridurre l'effetto antiaggregante dell'acido acetilsalicilico. La contemporanea somministrazione \u003Cbr\u002F>di steroidi aumenta il rischio di ulcere ed emorragie\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Amlodipina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antipertensivo \u003Cbr\u002F>calcioantagonista\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Aumento \u003Cbr\u002F>del volume gengivale, \u003Cbr\u002F>eritema multiforme, xerostomia, \u003Cbr\u002F>disgeusia, angioedema\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS e corticosteroidi: antagonismo dell'effetto ipotensivo\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Furosemide\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>diuretico \u003Cbr\u002F>dell'ansa\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Pemfigoide, xerostomia, \u003Cbr\u002F>angioedema, eritema multiforme, lesioni lichenoidi\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: la furosemide aumenta il rischio di ototossicità di amminoglicosidi, polimixine e vancomicina. \u003Cbr\u002F>l corticosteroidi aumentano II rischio di ipocaliemia\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Lansoprazolo\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antiulcera inibitore di pompa protonica\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, xerostomia, eritema \u003Cbr\u002F>multiforme, disgeusia\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: quando somministrato con claritromicina \u003Cbr\u002F>aumenta la concentrazione plasmatica \u003Cbr\u002F>di entrambi i farmaci\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Atorvastatina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Ipolipemizzante Statina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, parestesie, eritema multiforme disgeusia\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: eritromicina e claritromicina aumentano il rischio di miosite associato all'uso delle statine Lo stesso effetto indesiderato può manifestarsi con l'utilizzo \u003Cbr\u002F>di alcuni composti antimicotici imidazolici e triazolici\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Levotiroxina sodica\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Ormone \u003Cbr\u002F>tiroideo\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Dolore \u003Cbr\u002F>alle ghiandole salivari, \u003Cbr\u002F>tumefazione, xerostomia\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: la rifampicina aumenta il metabolismo della levotiroxina\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Metformina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Ipoglicemizzante \u003Cbr\u002F>orale\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Disgeusia (sapore metallico)\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Cortisonici:\u003Cbr\u002F>riducono l'effetto ipoglicemizzante\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Omeprazolo\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antiulcera inibitore di pompa protonica\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, xerostomia, eritema multiforme. Disgeusia.\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: quando l'omeprazolo è somministrato con la claritromicina aumenta la concentrazione plasmatica di entrambi i farmaci. \u003Cbr\u002F>Può ridurre l'assorbimento di antimicotici quali itraconazolo\u003Cbr\u002F>e ketoconazolo \u003Cbr\u002F>\u003Cbr\u002F>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Rosuvastatina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Ipolipemizzante \u003Cbr\u002F>Statina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, \u003Cbr\u002F>parestesie\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: l'eritromicina riduce le concentrazioni plasmatiche \u003Cbr\u002F>della rosuvastatina \u003Cbr\u002F>\u003Cbr\u002F>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Enalapril\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antipertensivo ACE-inibitore\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, disgeusia, eritema \u003Cbr\u002F>multiforme, pemfigo, xerostomia, \u003Cbr\u002F>lesioni lichenoidi\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS: \u003Cbr\u002F>antagonismo dell'effetto ipotensivo e aumento del rischio d'insufficienza renale; con ketorolac e forse\u003Cbr\u002F>altri FANS, ipercaliemia\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Simvastatina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Ipolipemizzante\u003C\u002Fp>\u003Cp>Statina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, parestesie\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>AB: eritromicina e claritromicina aumentano il rischio di miosite associato all'uso delle statine. Lo stesso effetto indesiderato \u003Cbr\u002F>può manifestarsi con l'utilizzo di alcuni composti antimicotici \u003Cbr\u002F>imidazolici e triazolici\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Nitroglicerina\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Vasodilatatore \u003Cbr\u002F>Nitrati\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Bruciore \u003Cbr\u002F>sublinguale, xerostomia\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS e corticosteroidi: antagonismo dell'effetto ipotensivo\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Pantoprazolo\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antiulcera inibitorg di pompa protonica\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Angioedema, xerostomia, eritema multiforme, disgeusia\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antimicotici: può ridurre l'assorbimento di itraconazolo e ketoconazolo \u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr>\u003Ctd>\u003Cp>Valsartan\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Antipertensivo Antagonista dell'angiotensina II\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>Disgeusia, angioedema pemfigoide\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd>\u003Cp>FANS: antagonismo dell'effetto ipotensivo e aumento del rischio \u003Cbr\u002F>d'insufficienza renale; aumento del rischio di ipercaliemia \u003Cbr\u002F>con ketorolac \u003Cbr\u002F>Corticosteroidi: antagonismo dell’effetto ipotensivo\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>A cura di: \u003Cb>\u003Ca href=\"http:\u002F\u002Fit.linkedin.com\u002Fpub\u002Ffrancesca-ibertis\u002F52\u002F240\u002Fa59\">Francesca Ibertis\u003C\u002Fa>\u003C\u002Fb> odontoiatra libero professionista\u003C\u002Fp>","cc9d7d14-397a-472c-b99c-11c5993f28cd","published","public","2013-06-28T00:00:00+00:00","2026-08-07T09:29:01.673541+00:00","'15':142C '2011':152C '3\u002F2013':17B,44C 'ab':335C,455C,486C,507C,547C,577C,609C,655C 'ace':349C,621C 'ace-inibitor':348C,620C 'acetilsalicil':380C,412C 'acid':379C,411C 'affett':114C 'alcun':170C,290C,531C,679C 'altre':180C,252C 'altri':341C,376C,395C,647C 'ambit':96C 'amlodipin':425C 'amminoglicosid':464C 'angioedem':298C,351C,382C,436C,450C,481C,502C,572C,607C,623C,653C,704C,725C 'angiotensin':722C 'ansa':447C 'antagon':361C,440C,632C,694C,720C,728C,747C 'antiaggreg':409C 'antibiot':109C,334C 'antidolorif':246C 'antimicot':533C,599C,681C,709C 'antimicrob':244C 'antinfiamm':111C,336C 'antipertens':347C,426C,619C,719C 'antiulcer':179C,476C,567C,699C 'assoc':516C,664C 'assorb':597C,713C 'atorvastatin':499C 'attenzion':3A,231C 'attiv':83C,140C,208C,325C 'aument':175C,366C,397C,418C,428C,458C,470C,491C,511C,550C,586C,637C,659C,733C,739C 'autor':126C,320C 'avvers':19B,46C,74C,223C,328C 'baruzz':30B,57C 'bocc':285C 'brevett':190C 'bruc':287C 'brucior':688C 'cadmos':15B,42C 'calcioantagon':427C 'cap':98C 'cas':194C,291C 'categor':326C 'claritromicin':490C,510C,585C,658C 'clinic':2A 'collateral':402C 'compost':532C,680C 'comun':93C 'concentr':493C,588C,614C 'concomit':393C 'consider':241C 'consult':70C,162C 'contemporane':414C 'corticosteroid':439C,469C,693C,746C 'cortison':561C 'costant':174C 'cur':752C 'd':369C,640C,736C 'dat':130C 'databas':135C 'dental':14B,41C,353C 'devan':28B,55C 'discrom':352C 'disgeus':284C,354C,435C,485C,506C,558C,576C,624C,708C,724C 'disturb':295C 'diuret':445C 'div':134C 'dolor':541C 'dossier':11B,38C 'dov':186C 'effett':256C,267C,363C,401C,408C,442C,523C,564C,634C,671C,696C,730C,749C 'emorrag':383C,424C 'enalapril':618C 'entit':271C 'entramb':496C,591C 'eritem':300C,355C,385C,432C,451C,483C,504C,574C,625C,706C 'eritromicin':508C,611C,656C 'erosion':387C 'es':177C,197C 'estrapol':132C 'event':222C 'facilit':163C 'fans':339C,360C,377C,381C,390C,396C,437C,631C,648C,691C,727C 'farmac':8A,76C,92C,106C,235C,309C,342C,498C,593C 'farmaceut':195C 'farmacolog':22B,49C 'fastid':278C 'ficarr':33B,60C 'forn':64C 'fors':375C,646C 'francesc':754C 'furosemid':444C,457C 'g':32B,34B,59C,61C 'general':89C,224C,262C 'gengival':384C,431C 'gestion':165C 'ghi':543C 'grad':216C 'grav':296C 'guid':156C 'ibertis':755C 'ibuprofen':404C 'ii':471C,723C 'imidazol':534C,682C 'impenn':183C 'incroc':128C 'indesider':524C,672C 'inibitor':350C,477C,568C,622C 'inibitorg':700C 'innocu':242C 'instaur':220C 'insufficient':370C,641C,737C 'inter':5A,21B,48C,79C,332C 'interag':250C 'interess':9B,24B,36C,51C,227C,330C 'ipercaliem':378C,649C,743C 'ipocaliem':474C 'ipoglicemizz':556C,565C 'ipolipemizz':500C,605C,651C 'ipotens':364C,443C,635C,697C,731C,750C 'ital':146C 'itraconazol':601C,715C 'ketoconazol':603C,717C 'ketorolac':373C,644C,745C 'lansoprazol':475C 'lesion':453C,629C 'levotiroxin':537C,554C 'liber':757C 'lichenoid':454C,630C 'liev':270C 'lod':35B,62C 'maggior':264C,310C 'manifest':294C,526C,674C 'mes':150C 'met':307C 'metabol':552C 'metall':560C 'metformin':555C 'mios':515C,663C 'molecol':248C 'molt':277C 'multiform':301C,356C,386C,433C,452C,484C,505C,575C,626C,707C 'multiterap':169C 'n':16B,43C 'nitr':687C 'nitroglicerin':685C 'noc':257C 'not':203C 'nov':149C 'numer':123C 'odontoiatr':25B,52C,66C,97C,228C,331C,345C,756C 'ogni':137C 'omeprazol':566C,580C 'oral':557C 'ormon':539C 'ototoss':462C 'otten':153C 'paes':213C,314C 'pantoprazol':698C 'parestes':503C,608C,654C 'part':192C,265C 'particol':108C 'patolog':117C 'pazient':113C,167C,276C 'pemfig':357C,627C 'pemfigoid':448C,726C 'plasmat':494C,589C,615C 'polimixin':465C 'pomp':479C,570C,702C 'port':218C,254C 'poss':293C 'possibil':72C 'potenzial':302C 'pratic':102C 'prescritt':85C,144C,311C 'prescriv':105C 'prescrizion':171C,233C 'prim':148C 'princip':82C,139C,207C,324C 'profession':758C 'proton':480C,571C,703C 'pubblic':12B,39C,318C 'può':405C,525C,594C,673C,710C 'qual':297C,600C 'quand':487C,578C 'quind':119C,230C 'quotidian':103C 'ramipril':346C 'rapid':161C 'reazion':18B,45C,73C,327C 'renal':371C,642C,738C 'riassunt':157C 'ricerc':1A 'riduc':562C,612C 'ridurr':406C,595C,711C 'rifampicin':549C 'ripropong':323C 'risc':368C,399C,420C,460C,472C,513C,639C,661C,735C,741C 'rosuvastatin':604C,617C 'routin':238C 's':27B,54C 'sal':88C,261C 'salivar':544C 'sapor':559C 'scad':188C 'scaten':303C 'scialorre':358C 'scientif':131C 'simvastatin':650C 'singol':138C 'sodic':538C 'somministr':415C,488C,582C 'sostanz':124C,253C 'spess':99C,240C,249C 'stat':259C 'statin':501C,520C,606C,652C,668C 'steroid':417C 'steroide':338C 'stess':522C,670C 'strument':68C 'sub':181C 'sublingual':689C 'tabell':160C,317C 'terap':121C 'tiroide':540C 'triazol':536C,684C 'tumef':545C 'ulcer':389C,422C 'uso':392C,518C,666C 'util':155C,315C 'utilizz':94C,210C,236C,344C,529C,677C 'v.martini':31B,58C 'valsartan':199C,718C 'vancomicin':467C 'vasodilat':686C 'vend':185C 'volum':430C 'xerostom':281C,359C,434C,449C,482C,546C,573C,628C,690C,705C",[],3105,[],[228],{"categories":229,"category_id":20},{"name":21,"path":22,"slug":22},{"bio":231,"title":8,"last_name":8,"avatar_url":8,"first_name":232,"is_organization":9},"Notizie e aggiornamenti dal mondo dell'odontoiatria.","Redazione ilDentale",[234,244,254],{"id":235,"title":236,"slug":237,"category_prefix":22,"excerpt":238,"cover_image_url":8,"access_level":220,"published_at":239,"article_categories":240,"authors":243},"b25a1b1b-5941-4e73-857d-75a4bed2f99e","Al via la terza edizione del Master in “Sviluppo della salute del cavo orale nelle comunità svantaggiate e nei Paesi in via di sviluppo”","via-terza-edizione-master-sviluppo-salute-cavo-orale","Sono disponibili ancora qualche posto per la terza edizione del Master di primo livello in “Sviluppo della salute del cavo orale nelle comunità svantaggiate e nei Paesi in via di sviluppo. Il Master…","2009-10-23T00:00:00+00:00",[241],{"categories":242,"category_id":20},{"name":21,"path":22,"slug":22},{"title":8,"last_name":8,"first_name":232},{"id":245,"title":246,"slug":247,"category_prefix":22,"excerpt":248,"cover_image_url":8,"access_level":220,"published_at":249,"article_categories":250,"authors":253},"d46f103e-bad1-480f-ab38-bb97eb4582f8","Pubblicità sanitaria: come comportarsi","pubblicita-sanitaria-comportarsi","L'avv. Silvia Stefanelli spiega la normativa sulla pubblicità sanitaria. Un video corso utile per capire come comportarsi su di una materia non ancora compresa fino in fondo dai professionisti sia in…","2008-11-16T00:00:00+00:00",[251],{"categories":252,"category_id":20},{"name":21,"path":22,"slug":22},{"title":8,"last_name":8,"first_name":232},{"id":255,"title":256,"slug":257,"category_prefix":22,"excerpt":258,"cover_image_url":8,"access_level":220,"published_at":259,"article_categories":260,"authors":263},"df38f461-fa94-491f-b315-4faa5387c778","Videointervista al prof. Enrico Gherlone referente per l’odontoiatria presso il ministero del Welfare","videointervista-prof-enrico-gherlone-referente-odontoiatria","Il lavoro della commissione per l’odontoiatria nata all’interno del Ministero del Lavoro, della Salute e delle Politiche sociali, il progetto di odontoiatria sociale, lo stato di 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